Fig. 5

Ac2-26 does not change density of microglial cells during pneumococcal meningitis. a Coronal brain sections were stained with antibodies against ionized calcium-binding adaptor molecule 1 (IBA-1) to identify activated microglial cells 28 h after infection with Streptococcus pneumoniae. The right column shows the dentate gyrus in higher magnification (scale bar = 100 μm). b IBA-1 immunoreactive cells were quantified, and the results are shown as cells per mm² area of dentate gyrus (all groups n = 5; two-way ANOVA followed by Bonferroni test; p > 0.05 compared to infected WT mice)