Bacterial load (log CFU/ml) |
|---|
| | Blood | Spleen | Cerebellum |
|---|
WT | 5.3 (4.5/6) | 5.1 (4.6/5.6) | 6.2 (5.6/7) |
WT + Ac2-26 | 4.5 (3.5/6.3) | 5 (3.5/7.7) | 4.5 (3.3/5)** |
Fpr1−/− | 8 (6.7/9.9) | 7 (7/8.7)### | 9 (7.1/10.1)### |
Fpr1−/− + Ac2-26 | 6.3 (6/7) | 7.2 (6.3/7.5) | 5.4 (5/7.5)** |
Fpr2−/− | 6 (5/7.5) | 6 (5/7.2)# | 6.9 (6/8.7) |
Fpr2−/− + Ac2-26 | 5.3 (5/5.8) | 5.3 (4.9/6.4) | 6.2 (4/9) |
- Data are presented as median (25th/75th percentile). Note significantly increased bacterial loads in the spleen of infected Fpr1−/− or Fpr2−/− mice and cerebellum of infected Fpr1−/− mice compared to infected WT mice (n ≥ 10 each group; Mann-Whitney U test; ###p = 0.0008 or p = 0.0001 for Fpr1−/− vs. WT; #p = 0.04 for Fpr2−/− vs. WT), and decreased bacterial loads in the cerebellum of infected WT or Fpr1−/− mice with Ac2-26 compared to infected WT or Fpr1−/− mice without Ac2-26 (n ≥ 10 each group; Mann-Whitney U test; **p = 0.004 for WT vs. WT + Ac2-26; p = 0.007 for Fpr1−/− vs. Fpr1−/− + Ac2-26) (CFU, colony-forming units; WT, wild type)
