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Table 3 Effect of the LPS and/or BA injection on the neurotransmitter concentrations in plasma and brain

From: Consecutive intra-gingival injections of lipopolysaccharide and butyric acid to mice induce abnormal behavior and changes in cytokine concentrations

Parameters

Groups

Brain

Plasma

Tyr

Trp

GABA

Ach

DA

5-HT

KA

Tyr

Trp

GABA

Neurotransmitter concentrations (μmol/L)

C

530

267

8,320

12.9

91.0

0.15

0.31

134

11.4

0.36

B

605

234

8,070

8.7

87.6

0.15

0.35

210

10.2

0.36

L

485

224

7,980

21.4

101.9

0.16

0.32

113

12.9

0.35

BL

514

235

7,991

20.7

100.2

0.16

0.32

137

10.3

0.42

pooled SE

22

9

103

2.1

5.2

0.01

0.01

12

1.1

0.05

Randomized block design 2-way ANOVA p value

Repeat

0.04

0.78

0.71

0.003

<0.001

0.001

0.31

<0.001

0.99

<0.001

LPS

0.10

0.23

0.26

0.01

0.24

0.45

0.71

0.02

0.75

0.67

BA

0.66

0.75

0.21

0.67

0.93

0.85

0.41

0.007

0.41

0.39

Interaction

0.23

0.68

0.39

0.82

0.7

0.56

0.46

0.07

0.76

0.45

  1. No concentration of 3-Hydroxy kynurenine or adrenaline was detected in the samples
  2. The concentrations of Ach, DA, 5-HT and KA in blood plasma were too low to be detected by the analysis
  3. CO control group, BA Butyrate group, LP Lipopolysaccharide group, BL Butyrate and lipopolysaccharide group, Tyr tyrosine, Trp tryptophan Trp, GABA gamma amino butyric acid, ACh acetylcholine, DA dopamine, 5-HT serotonin, KA kynurenic acid