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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Ocular macrophage origin and heterogeneity during steady state and experimental choroidal neovascularization

Fig. 3

Ablated MHCII+CD11c and decreased MHCII+CD11c+ macrophage numbers in Ccr2/ mice in response to laser injury. a Representative flow cytometry pseudocolor plots from wildtype and Ccr2/ female mice from day 0, day 3, day 5, and day 7. MHCII+CD11c macrophage numbers peaked in WT mice on day 3 and were completely unchanged in Ccr2/ female (b) and male (c) mice. MHCII+CD11c+ macrophage numbers peaked in WT mice on day 3 and were blunted in Ccr2/ female (d) and male (e) mice. *p < 0.05; **p < 0.01; ***p < 0.001. Colored asterisk = significant difference from day 0 within genotype (blue = WT, red = Ccr2/ mice). Black asterisk = significant difference between genotypes on day 3, day 5, or day 7. N = 8–11 per group in both male and female mice. Macrophage numbers were compared using the Brown-Forsythe and Welch ANOVA followed by Dunnett’s T3 multiple comparison

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