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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Ocular macrophage origin and heterogeneity during steady state and experimental choroidal neovascularization

Fig. 8

Model of ocular macrophage lineage during steady state and laser injury. a At steady state, microglia (red) and MHCII- macrophages (green) are tissue resident, self-sustaining, and long-lived macrophages. MHCII+ macrophages (CD11c [gray] and CD11c+[blue]) are partially self-sustaining and partially recycled from the peripheral blood monocyte pool (numbers indicate percentage replenished from blood monocytes). b After laser injury, MHCII macrophages (green) are derived from classical monocytes (90%) and from expanded tissue resident macrophages (10%). MHCII+CD11c macrophages (gray) are 100% derived from classical monocytes. MHCII+CD11c+ macrophages are derived from classical monocytes (70%), non-classical monocytes (20%), and expanded tissue resident macrophages (10%)

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