Fig. 8

Model of ocular macrophage lineage during steady state and laser injury. a At steady state, microglia (red) and MHCII^- macrophages (green) are tissue resident, self-sustaining, and long-lived macrophages. MHCII+ macrophages (CD11c⁻ [gray] and CD11c⁺[blue]) are partially self-sustaining and partially recycled from the peripheral blood monocyte pool (numbers indicate percentage replenished from blood monocytes). b After laser injury, MHCII⁻ macrophages (green) are derived from classical monocytes (90%) and from expanded tissue resident macrophages (10%). MHCII⁺CD11c⁻ macrophages (gray) are 100% derived from classical monocytes. MHCII⁺CD11c⁺ macrophages are derived from classical monocytes (70%), non-classical monocytes (20%), and expanded tissue resident macrophages (10%)