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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Complement peptide C3a receptor 1 promotes optic nerve degeneration in DBA/2J mice

Fig. 1

C3ar1 deficient DBA/2J mice developed iris disease and ocular hypertension similar to C3ar1 sufficient mice. a Regular anterior eye exams were performed using broad beam and transillumination. The pattern of iris depigmentation observed was similar in C3ar1+/+ (not shown) and C3ar1−/− mice (N = 80). b Elevated IOP compared to young mice was observed in a small subset of mice at 8 months of age and became more prevalent in older mice. No significant difference in IOP was found in C3ar1−/− mice compared to C3ar1+/+ mice at any age (8 mos., N = 80, P = 0.44; 10 mos., N = 80, P = 0.23; 12 mos., N = 80, P = 0.19). Boxes define the 75th and 25th percentiles and their middle line indicates the median value. The diamonds define the 95% confidence interval and their middle line indicates the mean value

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