Fig. 5
From: Complement peptide C3a receptor 1 promotes optic nerve degeneration in DBA/2J mice
Network analyses identified clusters of changes in neuroinflammation and IL10 signaling pathway gene expression. a Top 20 canonical pathways in IPA ranked by P value for enrichment in genes differentially expressed between C3ar1−/− and C3ar1+/+ microglia. b A network of canonical pathways was generated with edges representing that more than 5 genes were shared between two pathways. This network identified that the pathways shown in (a) had common biological function related to neuroinflammation (salmon) and immune cell activation (yellow). c Top 20 upstream regulators in IPA ranked by P value for enrichment in regulating genes differentially expressed between C3ar1−/− and C3ar1+/+ microglia. d A network of upstream regulators was generated with edges representing that more than 5 genes were shared between two upstream regulators. Only endogenous upstream regulators were included in the network. IL10 had the most connections to other upstream regulators (thick gray edges) and is a potential driver of changes associated with C3ar1 deficiency