Skip to main content
Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Minocycline reduces inflammatory response and cell death in a S100B retina degeneration model

Fig. 1

Study timeline. In this study, two different concentrations of minocycline (25 mg/kg body weight; 50 mg/kg body weight) were intraperitoneally injected at day -1. S100B or its solvent PBS were intravitreally applied at day 0. The untreated eyes were used as naïve controls. Minocycline was then administered daily (13.5 mg/kg body weight; 25 mg/kg body weight) from day 1 to 14. Five groups were generated in this study: naïve: untreated (n = 14); PBS: intravitreal PBS injection (n = 14); S100B: intravitreal S100B injection (n = 13); 13.5 mg/kg mino: low minocycline dose of 13.5 mg/kg + S100B (n = 15); 25 mg/kg mino: high minocycline dose of 25 mg/kg + S100B (n = 15). After 14 days, Electroretinogramm (ERG) measurements were carried out and the eyes and optic nerves were obtained for further analysis, including (immuno-)histology and proteomics

Back to article page