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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Minocycline reduces inflammatory response and cell death in a S100B retina degeneration model

Fig. 7

Top canonical pathways annotation analysis of the differentially abundant proteins. a Comparison analysis between the designated groups shows the canonical pathways, which were significantly modulated in the retinal samples. Bar charts depict the significantly negative log10-transformed p values (p < 0.05) enriched canonical pathways. b Heat maps of proteins associated with glycolysis I and mitochondrial dysfunction in the comparison analysis between the designated groups. Colours red and green represent increment and decrement of protein abundance, respectively, with different colour intensities that correspond to the degree of differential expression. c Pyruvate kinase (PKM, red) and cell nuclei (DAPI, blue) were stained in retinal cross-sections. PKM was mainly localized in GCL, INL, INL, and OS. d PKM staining area was significantly smaller in the S100B group than in the naïve and PBS group. GCL: ganglion cell layer, IPL: inner plexiform layer, INL: inner nuclear layer, OPL: outer plexiform layer, ONL: outer nuclear layer, OS: photoreceptor outer segments. Scale bar = 20 μm, n = 6/group, *p < 0.05 vs. naïve group, #p < 0.05 vs. PBS group

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