Fig. 9
From: Minocycline reduces inflammatory response and cell death in a S100B retina degeneration model
Top upstream regulators analysis of the differentially abundant proteins. a The top upstream regulators of the differentially expressed retinal proteins associated with different treatment paradigms. Z-scores are represented by the colour orange, which indicates activation, and blue, which indicates inhibition of the associated diseases and biological functions. b Network of proteins associated with TGFB1 in the comparison analysis between 13.5 mg/kg mino and PBS. Colours red and green represent increment and decrement of protein abundance, respectively, with different colour intensities that correspond to the degree of differential expression. Proteins are depicted as different shapes, which represent the functional classes of the proteins (e.g., enzyme, transporter, ion channel)