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Table 3 RBPMS, cleaved caspase 3, Iba1, Tmem119, and ED1 cell counts (cells/mm in the retina and mm2 in the optic nerve), PKM, GFAP, and S100B area evaluations (%), as well as SMI-32 and H&E scores for immunofluorescence stains in naïve, PBS, S100B, 13.5 mg/kg mino, and 25 mg/kg mino animals. Values are displayed as mean ± SEM. p values < 0.05 are shown in bold

From: Minocycline reduces inflammatory response and cell death in a S100B retina degeneration model

 

Cell type

Mean ± SEM

P-values

  

Naïve

PBS

S100B

13.5 mg/kg mino

25 mg/kg mino

Naïve vs. PBS

Naïve vs. S100B

Naïve vs. 13.5 mg/kg mino

Naïve vs. 25 mg/kg mino

PBS vs. S100B

PBS vs. 13.5 mg/kg mino

PBS vs. 25 mg/kg mino

S100B vs. 13.5 mg/kg mino

S100B vs. 25 mg/kg mino

13.5 vs. 25 mg/kg mino

Retina

RBPMS+

276.8 ± 13.6

266.3 ± 19.0

161.1 ± 22.9

230.3 ± 28.5

236.0 ± 22.0

1.00

0.008

0.56

0.68

0.02

0.77

0.86

0.20

0.14

1.00

Cl. casp. 3+ + Brn3a+

2.6 ± 0.5

3.5 ± 1.7

9.5 ± 1.0

3.3 ± 0.8

6.2 ± 1.4

1.00

0.002

1.00

0.20

0.008

1.00

0.45

0.006

0.27

0.40

Iba1+

10.1 ± 1.0

11.7 ± 0.5

19.0 ± 0.8

11.1 ± 0.8

11.5 ± 1.0

0.66

< 0.001

0.90

0.74

< 0.001

1.00

1.00

< 0.001

< 0.001

1.00

Tmem119 + Iba1+

9.7 ± 0.9

11.3 ± 0.4

18.6 ± 0.7

10.9 ± 0.7

10.9 ± 0.9

0.57

< 0.001

0.77

0.78

< 0.001

1.00

1.00

< 0.001

< 0.001

1.00

Tmem119- + Iba1+

3.0 ± 1.5

3.0 ± 1.5

3.0 ± 1.5

1.5 ± 0.9

1.5 ± 0.9

1.00

1.00

0.92

0.92

1.00

0.92

0.92

0.92

0.92

1.00

ED1+ + Iba1+

1.3 ± 0.4

2.4 ± 0.9

5.2 ± 1.2

2.5 ± 1.4

2.4 ± 1.3

0.48

< 0.001

0.40

0.48

0.002

1.00

1.00

0.002

0.002

1.00

PKM+

14.8 ± 4.8

14.9 ± 5.3

7.5 ± 1.9

10.1 ± 3.9

9.8 ± 3.6

1.00

0.03

0.29

0.24

0.03

0.26

0.22

0.81

0.86

1.00

GFAP+

3.1 ± 0.4

3.7 ± 0.4

3.1 ± 0.4

3.1 ± 0.3

4.3 ± 0.6

0.90

1.00

1.00

0.38

0.90

0.86

0.88

1.00

0.38

0.33

S100B+

9.3 ± 1.8

8.0 ± 2.1

7.7 ± 0.9

8.5 ± 2.8

9.5 ± 1.8

0.78

0.66

0.96

1.00

1.00

1.00

0.66

0.96

0.52

0.90

Optic nerve

SMI-32

0.7 ± 0.1

0.8 ± 0.1

1.3 ± 0.0

0.9 ± 0.1

1.0 ± 0.1

0.61

< 0.001

0.20

0.02

0.003

0.93

0.34

0.02

0.19

0.79

Cl. casp. 3+

42.6 ± 5.1

43.1 ± 4.6

84.9 ± 8.6

45.0 ± 6.3

59.0 ± 9.2

1.00

0.004

1.00

0.53

0.003

1.00

0.51

0.004

0.10

0.63

Iba1+

78.5 ± 6.0

83.7 ± 4.4

130.0 ± 9.3

72.4 ± 11.8

90.4 ± 10.6

1.00

0.003

1.00

0.87

0.009

0.90

0.98

0.001

0.03

0.61

Tmem119+ + Iba1+

77.0 ± 6.1

80.7 ± 3.8

124.1 ± 9.2

70.2 ± 11.7

87.4 ± 10.1

1.00

0.006

0.98

0.91

0.01

0.91

0.98

0.002

0.04

0.63

Tmem119- + Iba1+

1.5 ± 0.9

3.0 ± 1.5

6.3 ± 3.0

2.2 ± 1.0

3.0 ± 1.9

0.97

0.35

1.00

0.97

0.69

1.00

1.00

0.51

0.69

1.00

ED1+ + Iba1+

65.4 ± 10.6

85.7 ± 11.8

163.3 ± 14.0

85.1 ± 7.0

84.5 ± 10.0

0.69

< 0.001

0.70

0.73

< 0.001

1.00

1.00

< 0.001

< 0.001

1.00

H&E

0.7 ± 0.2

1.0 ± 0.2

1.9 ± 0.2

0.8 ± 0.2

1.1 ± 0.2

0.83

0.003

0.98

0.66

0.04

0.99

1.00

0.01

0.08

0.92

GFAP+

13.2 ± 1.2

13.7 ± 2.2

21.8 ± 2.2

18.8 ± 2.1

19.5 ± 2.0

1.00

0.04

0.30

0.20

0.06

0.38

0.26

0.82

0.92

1.00

S100B+

9.6 ± 1.4

10.4 ± 1.7

8.3 ± 2.4

9.4 ± 1.6

7.3 ± 0.7

1.00

0.98

1.00

0.85

0.89

0.99

0.68

0.99

0.99

0.89