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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Chemokine CXCL13 acts via CXCR5-ERK signaling in hippocampus to induce perioperative neurocognitive disorders in surgically treated mice

Fig. 6

Deletion of CXCR5 alleviates PND-like cognitive deficits in mice. WT or mice lacking the CXCR5 gene (CXCR5−/−) were subjected to surgery (denoted as “surgery”). Mice that did not undergo surgery were denoted “control.” All mice were tested in the Barnes maze and fear conditioning tests at 7 days after surgery. a Time to identify the target hole during training sessions and b latency time during memory phases of the Barnes maze. In the fear conditioning test, freezing times were quantified c in context and d in response to a cue. e Western blot and densitometry of hippocampal CXCR5, as well as f RT-qPCR analysis of the corresponding mRNA. All quantitative results (mean ± SD) shown were obtained with n = 8 animals per group. *P < 0.05 vs. WT + control; #P < 0.05 vs. WT + surgery. CXCR5 C-X-C motif chemokine receptor 5, RT-qPCR reverse transcription-quantitative polymerase chain reaction, WT wild-type

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