Fig. 7

CXCR5 deficiency inhibits surgery-induced p-ERK activation and release of inflammatory cytokines in mouse hippocampus. a Western blotting analysis of total ERK and p-ERK (n = 8 per group). b Representative images of p-ERK immunohistochemistry in the hippocampus. Positive cells are stained brown. Magnification, × 5 for total hippocampus; × 20 for hippocampal CA1, CA3, and DG (n = 4 per group). c Western blot and densitometry of IL-1β and TNF-α in the hippocampus. β-actin was used as an internal control (n = 8 per group). *P < 0.05 vs. control; ^#P < 0.05 vs. surgery. CXCR5 C-X-C motif chemokine receptor 5, DG dentate gyrus, WT wild-type