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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Chemokine CXCL13 acts via CXCR5-ERK signaling in hippocampus to induce perioperative neurocognitive disorders in surgically treated mice

Fig. 8

ERK-dependent production of pro-inflammatory cytokines in hippocampus mediates PND-like cognitive deficits in mice. Mice subjected to surgery were pretreated with vehicle or PD98059, and behavioral tests were conducted 7 days after the surgery. a Time to find the target hole during training sessions and b latency time during memory phases were assessed in the Barnes maze. In the fear conditioning test, freezing times were quantified c in context and d in response to a cue. e Western blot and densitometry of hippocampal IL-1β and TNF-α protein levels. β-actin was used as an internal control. All quantitative results (mean ± SD) shown were obtained with n = 8 animals per group. *P < 0.05 vs. control; #P < 0.05 vs. surgery. TNF-α tumor necrosis factor alpha, IL- interleukin-1 beta

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