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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Electrostimulation of the carotid sinus nerve in mice attenuates inflammation via glucocorticoid receptor on myeloid immune cells

Fig. 3

CSN electrostimulation attenuates inflammation independently of the vagus nerve. ag Eight to 10-week-old C57BL/6 mice were anaesthetised; CSN was isolated and either cut (g) of left intact (af). Electrical stimulation was applied at 600 μA, 10 Hz (ae) or 200 μA, 5 Hz (f, g) 5 min before and after IP LPS injection (100 μg). Blood was collected 90 min after LPS injection for serum analysis by Meso Scale Discovery (ad) or ELISA (eg). Impact of electrical activation of the CSN on a LPS-induced serum TNF levels, b IL-1β, c IL-6 and d IL-12p70. e Impact of electrical activation of the CSN on LPS-induced serum TNF levels in the presence of oil. f Impact of unilateral left vagal removal on LPS-induced serum TNF levels following left CSN electrostimulation. All individual points represent one animal, and data is expressed as means ± SD. g Impact of afferent CSN stimulation on LPS-induced serum TNF levels

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