Fig. 4From: Diesel exhaust impairs TREM2 to dysregulate neuroinflammationTREM2 deficiency selectively augments cortical Il1b gene expression. Trem2−/− and Trem2+/+ mice were treated with DEP (100 μg/mouse IT, 2× per week, 4 weeks) or vehicle (IT, 2× per week, 4 weeks). mRNA levels were measured by qRT-PCR for Tnf (TNFα) (a, b) and Il1b (IL-1β) (c, d) in the cortex (a, c) or hippocampus (b, d) of mice. *p < 0.05, compared with controls (n = 3–6)Back to article page