Fig. 5
From: Diesel exhaust impairs TREM2 to dysregulate neuroinflammation
TREM2 deficiency augments neutrophilic pulmonary response to diesel exhaust particles. Trem2+/+ and Trem2−/− mice were treated with DEP (600 μg/mouse IT, single dose) or vehicle (IT, single dose). Total cell infiltration in bronchoalveolar lavage fluid (BALF) was analyzed by automated cell counter (a). Neutrophils were counted from Wright-Giemsa-stained cytospin preparations (b). Total protein in BALF was analyzed by BCA assay (c). Representative H&E-stained lung sections (d). *p < 0.05, compared with controls. #p < 0.05 compared between IT-DEP-exposed groups (n = 5–6)