Fig. 6

TREM2 regulates diesel exhaust particle-induced NADPH oxidase gene expression. Trem2^−/− and Trem2^+/+ mice were treated with DEP (100 μg/mouse IT, 2× per week, 4 weeks) or vehicle (IT, 2× per week, 4 weeks). mRNA levels were measured by qRT-PCR for Cybb (gp91^PHOX) (a, b), Ncf1 (p47^PHOX) (c, d), and Ncf2 (p67^PHOX) in the cortex (a, c, e) or hippocampus (b, d, f). *p < 0.05, compared with controls (n = 3–6)