Publication | APC (106) | MOG (aa35-55) | Anti-CD28 | Anti-CD3 | IL-12 | IL-2 | IL-18 | Anti-IL-4 | rmIFNγ | IL-23 | hTGF-β | IL-6 | Anti-IFNγ | Restimulation in vitro |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Williams et al. 2020 [48] | 5 | 10 μg/ml | / | / | 10 U/ml (Th1) | 10 U/ml (Th1) | / | / | / | / | / | / | / | Yes |
Stromnes et al. 2008 [4] | / | / | / | / | 10 ng/ml (Th1) | / | / | / | / | 10 ng/ml (Th17) | / | / | / | No |
Domingues et al. 2010 [19] | / | 20 μg/ml (MOG aa1-125) | / | / | 10 ng/ml (Th1) | 10 ng/ml at day 3 (Th1) | 25 ng/ml (Th1) | 10 μg/ml (Th1) (Th17) | / | 10 ng/ml (Th17) | 5 ng/ml (Th17) | 20 ng/ml (Th17) | / | Yes |
Kroenke et al. 2010 [49] |  | 4 days with MOG | / | / | 5 ng/ml (Th1) | / | / | 10 μg/ml (Th1) | 2 ng/ml (Th1) | / | / | / | / | No |
Rothhammer et al. 2011 [17] | Irradiated 1:5 ratio | 20 μg/ml (Th1) (Th17) | 2 μg/ml plate-bound (Th1) (Th17) | 4 μg/ml plate-bound (Th1) (Th17) | 10 ng/ml (Th1) | / | / | 10 μg/ml (Th1) (Th17) | / | 25 ng/ml (Th17) | 2 ng/ml (Th17) | 20 ng/ml (Th17) | / | Yes |
Jäger et al. 2009 [18] | Irradiated 1:5 ratio | 20 μg/ml | / | 2.5 μg/ml (Th1) (Th17) | 10 ng/ml (Th1) | / | / | 20 μg/ml (Th1) (Th17) | / | / | 3 ng/ml (Th17) | 30 ng/ml (Th17) | 20 μg/ml (Th17) | Yes |
Our protocol | Irradiated 1:5 (Th1) ratio 1:10 (Th17) | / | / | 2 μg/ml (Th1) (Th17) | 5 ng/ml (Th1) | / | 25 ng/ml (Th1) | 10 μg/ml (Th1) (Th17) | / | 20 ng/ml (Th17) | 3 ng/ml (Th17) | 20 ng/ml (Th17) | 10 μg/ml (Th17) | Yes |