Fig. 1

Effects of K284-6111 on memory impairment in Tg2576 mice. a A timeline has been described that demonstrates the administration of K284-6111 and the assessment of cognitive function in Tg2576 mice. To investigate the effect of K284-6111 on memory impairment, we carried out (b, c) the water maze test, (d) the probe test, and (e) the step-through type passive avoidance test. Memory and learning ability in Tg2576 were determined by the escape latencies (b, sec) and escape distance (c, cm) for 6 days, and time spent in the target quadrant (d, %) in the probe test