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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: K284-6111 alleviates memory impairment and neuroinflammation in Tg2576 mice by inhibition of Chitinase-3-like 1 regulating ERK-dependent PTX3 pathway

Fig. 2

Effect of K284-6111 on the deposition of Aβ and amyloidogenic factors in Tg2576 mice brain. a The accumulation of Aβ plaques in the hippocampus was determined by Thioflavin S staining. bThe levels of Aβ1-42 and (c) Aβ1-40 in Tg2576 mice brain were assessed using the specific ELISA kits. d The expression of APP and BACE1 were detected by Western blot. (e) The activity of β-secretase in mice brain was investigated by the β-secretase activity assay kit

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Journal of Neuroinflammation

ISSN: 1742-2094