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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: K284-6111 alleviates memory impairment and neuroinflammation in Tg2576 mice by inhibition of Chitinase-3-like 1 regulating ERK-dependent PTX3 pathway

Fig. 3

Inhibitory effect of K284-6111 on neuroinflammation in Tg2576 mice brain. a Expression of GFAP, IBA-1, iNOS, and COX-2 in Tg2576 mice hippocampus was determined by immunohistochemistry analysis. (b) Expression of iNOS, COX-2, GFAP, and IBA-1 was detected by Western blot. (c) The mRNA expression level of M1 microglia phenotype markers (Tnf, Il1b, Il6, and Cd86) and M2 microglia phenotype markers (Arg1, Mrc1, Tgfb, and Il10) were assessed by qRT-PCR

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