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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: K284-6111 alleviates memory impairment and neuroinflammation in Tg2576 mice by inhibition of Chitinase-3-like 1 regulating ERK-dependent PTX3 pathway

Fig. 4

Inhibitory effect of K284-6111 on Aβ-induced neuroinflammation in BV-2 cells. BV-2 cells were treated with Aβ (5 μM) and K284-6111 (0.5, 1, and 2 μM). a The inhibitory effect of K284-6111 on nitric oxide production was determined using a nitric oxide assay kit in BV-2 cells. b Expression of iNOS, COX-2, and IBA-1 was detected by Western blot. c The mRNA expression level of pro-inflammatory cytokines (Tnf, Il1b, and Il6) and M1 microglia phenotype marker (Cd86) were assessed by qRT-PCR. (D) The production levels of TNF-α, IL-1β, and IL-6 were assessed using the specific ELISA kits

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Journal of Neuroinflammation

ISSN: 1742-2094