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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: K284-6111 alleviates memory impairment and neuroinflammation in Tg2576 mice by inhibition of Chitinase-3-like 1 regulating ERK-dependent PTX3 pathway

Fig. 6

Inhibitory effect of K284-6111 on CHI3L1-induced neuroinflammation. BV-2 cells were transfected with CHI3L1 plasmid vector. After 24 hr, cells were treated with K284-6111 (5 μM). a Expression of iNOS, COX-2, and IBA-1 were detected by Western blot analysis using specific antibodies in BV-2 cells. b Level of p-ERK 1/2, ERK 1/2, p-IκBα, and IκBα were detected by Western blot. c The mRNA expression level of pro-inflammatory cytokines (Tnf, Il1b, and Il6) and M1 microglia phenotype marker (Cd86) in BV-2 cells were assessed by qRT-PCR

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