Fig. 1

Effect of SIS3 and LPS on motor behavior of rats in behavioral tests. a Representative movement paths of different groups in open field test on the 21st day after the last drug administration. The corresponding values of total distance, inactive time and rearing number are shown in the right table. b Total distance traveled in open field test. c Inactive time in open field test. d Number of rearing (both front paws of rats off the ground with or without forepaws against a wall) in open field test. e Time to cross beam in beam walk test. f Descent latency in grid test. g Descent latency in bar test. Results are expressed as mean ± SEM. N = 7. *p < 0.05, compared with the rats treated with vehicle; #p < 0.01, compared with the rats treated with vehicle; ▽p < 0.01, compared with the rats treated with vehicle or LPS; ▲p < 0.05, compared with the rats treated with vehicle, SIS3 or LPS; ▼p < 0.01, compared with the rats treated with vehicle, SIS3, or LPS. LPS, lipopolysaccharide (1 mg/kg); SIS3 (4 μg/each side)