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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Substantia nigra Smad3 signaling deficiency: relevance to aging and Parkinson’s disease and roles of microglia, proinflammatory factors, and MAPK

Fig. 4

Effect of SIS3 and LPS on proinflammatory factors in rats. a Representative figures of Smad3, pSmad3, and proinflammatory factor expression (western blotting). b–f Histogram represents quantitation of pSmad3 (b), Smad3 (c), IL-1β (d), IL-6 (e), and iNOS (f) normalized to corresponding GAPDH. g ROS production was determined by DCFHDA. Results are expressed as mean ± SEM. N = 6. #p < 0.01, compared with the rats treated with vehicle; ▼p < 0.01, compared with the rats treated with vehicle, SIS3, or LPS; +p < 0.05, compared with the rats treated with SIS3, or LPS. LPS, lipopolysaccharide (1 mg/kg); SIS3 (4 μg/each side)

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Journal of Neuroinflammation

ISSN: 1742-2094