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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Substantia nigra Smad3 signaling deficiency: relevance to aging and Parkinson’s disease and roles of microglia, proinflammatory factors, and MAPK

Fig. 8

Aging-related Smad3 and pSmad3 expression and proinflammatory factor levels in mouse SN. a Representative figures of Smad3 and pSmad3 expression (western blotting) in the SN and cerebellum of mice. bc Histogram represents quantitation of pSmad3 (b) and Smad3 (c) normalized to corresponding GAPDH. df mRNA levels of IL-1β (d), IL-6 (e), and iNOS (f) were detected by RT-qPCR in mouse SN. g Representative figures of proinflammatory factor expression (western blotting) in mouse SN. hj Histogram represents quantitation of IL-1β (h), IL-6 (i), and iNOS (j) normalized to corresponding GAPDH. k ROS production was determined with DCFHDA. Results are expressed as mean ± SEM. N = 6. #p < 0.01, compared with the young mice. SN, substantia nigra; CBM, cerebellum

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