Table 1 CNS cell-specific upregulation of complement component genes in humans and animal models of neurodegenerative diseases
From: The good, the bad, and the opportunities of the complement system in neurodegenerative disease
| AD | ALS | Stroke | Epilepsy | TBI | MS | |
|---|---|---|---|---|---|---|
| Microglia | C1q, C3, CR4, C3aR [16, 17] | CR4, C1q [22] | C1q [23] | ND | CR4, C1inh, C1s, C3, C4 [24] | C3, CD40, CR4, CR3 [25, 26] |
| Astrocytes | C4, C3, C1inh, clusterin [17, 21, 27] | ND | C4, C1rb, C1ra, C1s, C1inh [28] | ND | C1q [29] | C3, C1inh, CR4, C3, C4, C1q [30] |
| Neurons | C1q, C2, C3, C4, C5, C6, C7, C8, C9 [31] | C1q, C4, C3 [32], C1q, C5aR1; CD55 is downregulated [33, 34] | C5, C5aR [35, 36] | ND | ND | ND |
| Oligodendrocytes | C4 [18] | ND | ND | ND | ND | ND |