Skip to main content

Table 1 CNS cell-specific upregulation of complement component genes in humans and animal models of neurodegenerative diseases

From: The good, the bad, and the opportunities of the complement system in neurodegenerative disease

  AD ALS Stroke Epilepsy TBI MS
Microglia C1q, C3, CR4, C3aR [16, 17] CR4, C1q [22] C1q [23] ND CR4, C1inh, C1s, C3, C4 [24] C3, CD40, CR4, CR3 [25, 26]
Astrocytes C4, C3, C1inh, clusterin [17, 21, 27] ND C4, C1rb, C1ra, C1s, C1inh [28] ND C1q [29] C3, C1inh, CR4, C3, C4, C1q [30]
Neurons C1q, C2, C3, C4, C5, C6, C7, C8, C9 [31] C1q, C4, C3 [32], C1q, C5aR1; CD55 is downregulated [33, 34] C5, C5aR [35, 36] ND ND ND
Oligodendrocytes C4 [18] ND ND ND ND ND
  1. Italics=human tissue, ND not determined