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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: CCN3 is dynamically regulated by treatment and disease state in multiple sclerosis

Fig. 3

CCN3 is significantly upregulated in peripheral immune cells in MS. Fold change in CCN3 gene expression in PBMCs (a), CD4 (b) and CD4+ (c) peripheral immune cells in MS relative to age- and sex-matched healthy controls. The percentages of samples with detectable expression are indicated in red (left graphs, ac). CCN3 mRNA expression levels in healthy controls and MS patients stratified by disease phase and treatment (right graphs, ac). Abbreviations: HC, healthy control; MS, multiple sclerosis; RRMS, relapsing-remitting MS; TN, treatment-naïve; Nat, natalizumab treatment; IFN, interferon-β treatment; Prog MS, progressive MS

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