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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Neuroprotective epi-drugs quench the inflammatory response and microglial/macrophage activation in a mouse model of permanent brain ischemia

Fig. 1

The combination of MS-275 and resveratrol is neuroprotective two days after pMCAO. (a) Treatment with MS-275 (20 μg/kg) and resveratrol (680 μg/kg) reduced the infarct volume, determined 2 days after pMCAO. Silver-stained coronal brain sections showing infarcts in light grey are depicted on top of the panel. ANOVA, **P<0.01 ***P<0.001 (Bonferroni post hoc test). Values are means ± s.e.m. (n = 9-11 from five independent experiments). (b) In the corner test, vehicle-, MS-275- and resveratrol-treated mice showed a preference to turn to the right side 2 days after pMCAO. Treatment with MS-275 and resveratrol reduced this preference for right turns. The dashed line indicates the expected behaviour without a side preference. Two-way repeated-measures ANOVA, *P<0.05, ***P<0.001 (Bonferroni post hoc test). Values are means ± s.e.m. (n = 11-13 from five independent experiments). (c) Treatment with MS-275 and resveratrol improved the latency to move that was increased 2 days after pMCAO. Two-way repeated-measures ANOVA, *P<0.05 (Bonferroni post hoc test). Values are means ± s.e.m. (n = 11-13 from five independent experiments).

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