Fig. 4

The combination of MS-275 and resveratrol reduces immunoreactivity for CD45 1 day after pMCAO. (a) Representative images of CD45 immunoreactivity in the peri-infarct area of brain sections obtained from the contralateral and ipsilateral hemispheres of MCAO vehicle, and from the ipsilateral hemisphere of MCAO MS-275 (20 μg/kg) + resveratrol (680 μg/kg) mice. Scale bar: 120 μm. (b) Quantification of CD45 immunostaining displays an effect of MS-275 and resveratrol treatment in reducing leukocytes infiltration. Data (means ± s.e.m. of 36-48 frames/mouse, n = 3) are expressed as CD45 positive area in the ipsilateral hemisphere/ CD45 positive area in the contralateral hemisphere. Mann Whitney test, *p < 0.05.