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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Neurotransmitter and neuropeptide regulation of mast cell function: a systematic review

Fig. 1

The mast cell–nerve interaction: a paradigm of neuroimmune crosstalk. MCs express receptors for various neurotransmitters and neuropeptides and are modulated by them, allowing neural control of mast cell function. Conversely, mast cells also communicate with nerves by secreting mediators. Ach, acetylcholine; NO, nitric oxide; H2S, hydrogen sulfide; GABA, gamma-aminobutyric acid; DA: dopamine; SP, substance P; VIP, vasoactive intestinal peptide; CRH, corticotrophin-releasing hormone; CGRP, calcitonin gene-related peptide; NTs, neurotrophins; NT, neurotensin; PACAP, pituitary adenylate cyclase–activating polypeptide; ATP, adenosine triphosphate. This figure contains adapted images obtained from Servier Medical Art by Servier

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