Fig. 3

Subretinal distribution of IL-1β, inflammasome (NRLP3), and caspase-1 after blue light exposure (BLE). Representative confocal images showing co-immunoreactivity of a IL-1β (green), b NLRP3 (green), and c caspase-1 (green) with MPs F4/80⁺ cells (red) in the subretinal space of animals non-exposed (Control) and exposed to blue light (BLE) treated or not with rytvela. Cell nuclei were counterstained with DAPI (blue). Rytvela reduced immunoreactivity of IL-1β, NLRP3, and caspase-1. n = 4–5 per group. Scale bar 50 μm. ONL: outer nuclear layer; INL: inner nuclear layer