Fig. 3

CCL2 is elevated in CTE. Quantitative measurement of CCL2 protein levels in CTE a-c and AD d-f from the a, d dorsolateral frontal cortex (DLFC) (control n = 18, RHI without CTE n = 20, low CTE n = 27, high CTE n = 47, low AD n = 60, intermediate AD n = 28, high AD n = 24) and b, e calcarine cortex (control n = 13, RHI without CTE n = 16, low CTE n = 25, high CTE n = 42, low AD n = 34, intermediate AD n = 12, high AD n = 19). c, f To determine if CCL2 was specifically elevated in the DLFC, CCL2 in the DLFC was divided by CCL2 values in the calcarine cortex to obtain a ratio (control n = 13, RHI without CTE n = 16, low CTE n = 25, high CTE n = 42, low AD n = 37, intermediate AD n = 16, high AD n = 12). Values over 1 represent more CCL2 in the DLFC compared to the CC. Statistics were generated via a one-way ANOVA with a Kruskal-Wallis post-test comparing differences to the control cases. Each dot represents a single case. Error bars show median and interquartile range. *p < 0.05, **p < 0.01, ***p < 0.001 relative to control cases