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Fig. 4. | Journal of Neuroinflammation

Fig. 4.

From: CCL3 contributes to secondary damage after spinal cord injury

Fig. 4.

Smaller lesion sizes in CCL3−/− mice at day 5 after SCI. a Representative images of GFAP immunoreactivity (green) and myelin content (red), in wild-type and CCL3–/– mice at day 5 after SCI. Scale bars 200 μm. b Quantitative analysis revealing significantly smaller lesion size as a percentage of the total area at the epicenter in CCL3−/− compared to wild-type mice. c No difference was detected in the myelin content between groups. d Quantitative analysis revealing significantly smaller lesion proportions in CCL3−/− compared to wild-type mice, starting at 224 μm rostral and caudal from the epicenter. e Quantitative analysis revealing a significantly smaller number of astrocytes adjacent to the epicenter of the lesion in CCL3−/− compared to wild-type mice. f Representative confocal image with orthogonal view of GFAP immunoreactivity (green) and DAPI (blue). Scale bars 80 μm. n = 5/group. Data points represent mean ± SEM. * < p value 0.05

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