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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Deficiency of Nrf2 exacerbates white matter damage and microglia/macrophage levels in a mouse model of vascular cognitive impairment

Fig. 1

White matter disruption is more extensive in Nrf2-deficient mice following BCAS surgery. a White matter disruption was detected post-BCAS in the corpus callosum, with a significant effect of genotype (no post hoc differences). b There was no significant alteration in the levels of white matter disruption in the internal capsule when comparing experimental groups. c The optic tract displayed prominent white matter disruption post-BCAS with a further effect of genotype, with the Nrf2−/− group displaying the most severe disruption. Mean ± SEM. Group size presented in each bar. *p < 0.05, **p < 0.01, ***p < 0.001 (asterisk indicates post hoc differences between sham and BCAS), #p < 0.05, ##p < 0.01 (number sign indicates post hoc differences between BCAS groups). d Representative images of MAG immunostaining in the optic tract. Scale bar 50 μm

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