Fig. 2

The density of microglia/macrophages is increased after BCAS to a greater extent in Nrf2^−/− mice. There was an effect of BCAS surgery and genotype on density of Iba1 in the corpus callosum, with the Nrf2^−/− BCAS group displaying the highest density. b The effect of BCAS and genotype narrowly missed accepted levels of statistical significance in the internal capsule. c The optic tract displayed an increased density of Iba1 post-BCAS, with a further effect of genotype, with the Nrf2^−/− BCAS group displaying the highest density. Mean ± SEM. Group size presented in each bar. **p < 0.01, ***p < 0.001 (asterisk indicates post hoc differences between sham and BCAS), #p < 0.05, ##p < 0.01, ###p < 0.001 (number sign indicates post hoc differences between BCAS groups). d Representative images of Iba1 staining in the optic tract. Scale bar 50 μm