Fig. 6

Nrf2, Nrf-2-regulated antioxidant and pro-inflammatory genes in the optic tract after BCAS surgery. a There was a significant effect of genotype on Nrf2 expression but no effect of BCAS surgery. Nrf2 was reduced by ~ 50% in Nrf2^+/− mice and almost undetectable in Nrf2^−/− mice. b There was no effect of BCAS surgery or genotype on Slc7a11 or c Gclm expression; however, BCAS surgery increased the expression of d Ccl3 and e C1q. f The effect of BCAS surgery just missed accepted levels of statistical significance for C4 expression and there was no genotype effect on any gene. Gene expression was normalised to Gapdh and expressed as fold change compared to wild-type shams. Mean ± SEM. Group size presented in each bar. Dashed line indicates WT sham mean. *p < 0.05 (asterisk indicates post hoc differences between sham and BCAS groups), ##p < 0.01, ###p < 0.001 (number sign indicates differences between genotypes)