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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Deficiency of Nrf2 exacerbates white matter damage and microglia/macrophage levels in a mouse model of vascular cognitive impairment

Fig. 7

Behaviour assessed with radial arm maze is impaired after BCAS but is not exacerbated by deficiency in Nrf2. There was an effect of trial during both first (blocks 1–4) and second half (blocks 5–8) of the test indicating learning over time. During the second half of the test, revisiting errors were significantly higher post-BCAS demonstrating impaired spatial working memory. However, there was no effect of genotype on revisiting errors during either the first or second part of the test. Post hoc analyses identified no further significant differences. Mean ± SEM. *p < 0.05 (asterisk indicates main effect of BCAS surgery during second half of test). Group sizes are indicated in the graph

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