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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Mer regulates microglial/macrophage M1/M2 polarization and alleviates neuroinflammation following traumatic brain injury

Fig. 8

Inhibition of Mer abolished PS-mediated functional improvements following TBI. ac Representative immunoblots and quantification showing protein expression of p-STAT1 (a), SOCS-1 (b), and SOCS-3 (c) in the injured cortex at 3 days after TBI; TBI + vehicle: TBI + V, TBI + PS + control siRNA (si.Ctrl): TBI + S + C, TBI + S + Mer siRNA (si.Mer): TBI + S + M. GAPDH: loading control. Data are expressed as fold change compared to the TBI + V group; n = 6 mice per group. df Modified neurological severity scores (mNSS) (d), foot-fault test (e), and rotarod test (f) were performed at 3 days after TBI. n = 8 mice per group. In af, data are presented as mean ± SD; ***, p < 0.001. One-way ANOVA followed by Bonferroni’s post hoc tests

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