TY - JOUR AU - Biechele, Gloria AU - Franzmeier, Nicolai AU - Blume, Tanja AU - Ewers, Michael AU - Luque, Jose Medina AU - Eckenweber, Florian AU - Sacher, Christian AU - Beyer, Leonie AU - Ruch-Rubinstein, Francois AU - Lindner, Simon AU - Gildehaus, Franz-Josef AU - von Ungern-Sternberg, Barbara AU - Cumming, Paul AU - Bartenstein, Peter AU - Rominger, Axel AU - Höglinger, Günter U. AU - Herms, Jochen AU - Brendel, Matthias PY - 2020 DA - 2020/12/14 TI - Glial activation is moderated by sex in response to amyloidosis but not to tau pathology in mouse models of neurodegenerative diseases JO - Journal of Neuroinflammation SP - 374 VL - 17 IS - 1 AB - In vivo assessment of neuroinflammation by 18-kDa translocator protein positron-emission-tomography (TSPO-PET) ligands receives growing interest in preclinical and clinical research of neurodegenerative disorders. Higher TSPO-PET binding as a surrogate for microglial activation in females has been reported for cognitively normal humans, but such effects have not yet been evaluated in rodent models of neurodegeneration and their controls. Thus, we aimed to investigate the impact of sex on microglial activation in amyloid and tau mouse models and wild-type controls. SN - 1742-2094 UR - https://doi.org/10.1186/s12974-020-02046-2 DO - 10.1186/s12974-020-02046-2 ID - Biechele2020 ER -