Fig. 3

Sex effects on Aβ and tau overexpression in mouse models of neurodegenerative diseases. Cortical Aβ-PET quantification is illustrated as a function of age for female (blue) and male (yellow) mice, analyzed by mixed linear models, together with ¹⁸F-florbetaben Aβ-PET group mean images at different ages in a horizontal place (n = 6–15) projected upon a MRI standard. Serial scans in the upper part of the figure are indicated by connected data points. 95% confidence intervals are indicated in grey. a Female and male App^NL-G-F mice showed similar increases of Aβ-PET SUVR from 2.5 to 10 months with a slight offset across the whole observation period. b Female App^NL-G-F mice showed slightly higher terminal methoxy-X04 Aβ staining at 11 months when compared to males (p = 0.021). c P301S tau transgenic mice showed no sex differences in AT8 tau staining at 7–8 months of age (p = 0.965). FBB—florbetaben, PET—positron emission tomography, MRI—magnetic resonance imaging, SUVR—standardized uptake value ratio, Aβ—beta amyloid, M—months