Fig 1.

Spinal cord injury induces expression of inflammatory genes in the liver. Female C57BL/6 mice underwent either a 70kD SCI (black bars, N=4-5/time point) or sham surgery (white bars, n=5/time point). Tissue was collected at 2, 6, 12 and 24 hours post-operation and compared to naïve baseline (grey bar and dotted line, n=5). Relative hepatic expression levels of inflammatory genes IL-1β (a), CXCL10 (b), CXCL1 (c) and SAA-2 (d), and the IL-1 receptor antagonist IL-1RA (E) were determined by qPCR. Data are presented as mean ±SEM and were analysed by two-way ANOVA. *p<0.05, **p<0.01 with post-hoc test