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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: A novel long intergenic non-coding RNA, Nostrill, regulates iNOS gene transcription and neurotoxicity in microglia

Fig. 8

Impact of Nostrill induction on microglial-mediated neurotoxicity. a Impact of Nostrill knockdown on microglial-mediated neurotoxicity. BV2 cells were transfected with siRNA for 24 h, stimulated with LPS (10 μg/ml) for 6 h, then media was exchanged for fresh media. BV2 cells conditioned media for 72 h, before that media was placed on cortical cells. Cortical cells were stained with propidium iodide and Hoechst. Scale bar = 200 μm. Relative fluorescent units were quantified in (b). ***p < 0.001 vs siRNA- control. †††p < 0.001 between indicated groups. c Impact of Nostrill overexpression on microglial-mediated neurotoxicity. Cortical cells were stained with propidium iodide and Hoechst. Scale bar = 200 μm. Relative fluorescent units were quantified in (d). #p < 0.05, ###p < 0.001 vs empty vector. Data represent means ± SEM from three independent experiments

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