Fig. 2

Alterations in gut microbiota composition following chronic noise exposure. a The most differentially abundant taxa in each group identified by LDA scores generated from the LEfSe analysis (n = 5–6). b The enriched taxa in fecal microbiota of mice are represented in cladograms. The central point represents the root of the tree (bacteria), and each ring represents the next lower taxonomic level (phylum to genus). The diameter of each circle represents the relative abundance of the taxon (n = 5–6). c A heatmap showing Metastat analysis of species with significant differences between groups based on species abundance tables at the bacterial genus level. d–j Comparison of relative abundance at the bacterial genus level in all groups. *P < 0.05, **P < 0.01, vs. indicated group, Mann–Whitney U test. CON, control groups; NOISE, noise-exposed groups; WT, wild-type mice; APP/PS1, APP/PS1 transgenic mice; @, WT NOISE group vs. WT CON group; #, APP/PS1 CON group vs. WT CON group; &, APP/PS1 NOISE group vs WT CON group