Fig. 8From: Environmental noise stress disturbs commensal microbiota homeostasis and induces oxi-inflammmation and AD-like neuropathology through epithelial barrier disruption in the EOAD mouse modelChronic noise-induced Alzheimer’s disease-like neuropathological alterations in WT and APP/PS1 mice. a, b Enzyme-linked immunosorbent assay analysis of Aβ40 and Aβ42 content in each group (n = 6). c–f Western blot analysis (c) and quantification (d–f) of phosphorylated tau at AD-related sites in the hippocampus in each group (n = 5). GAPDH was used as a loading control. Data are presented as the percent change relative to control samples (n = 6). All data are presented as mean ± standard deviation. *P < 0.05, **P < 0.01 vs. WT CON group; #P < 0.05, ##P < 0.01 vs. APP/PS1 CON group. §, exposure effect, P < 0.05; ¶, genotype effect, P < 0.05; ǂ, interaction effect, P < 0.05. CON, control groups; NOISE, noise-exposed groups; WT, wild-type mice; APP/PS1, APP/PS1 transgenic miceBack to article page