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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Comparisons of neuroinflammation, microglial activation, and degeneration of the locus coeruleus-norepinephrine system in APP/PS1 and aging mice

Fig. 2

Microglia immunofluorescence in the spinal cord of APP/PS1 and WT mice. a Iba-1 expression in the lumbar spinal cord was detected by immunofluorescence. b Iba-1 expression in the two groups of mice increased significantly with aging. Iba-1+ area in 12-month-old APP/PS1 mice was significantly more than that of 12-month-old WT mice and 3-month-old APP/PS1 mice; it was even more than that in 24-month-old WT mice. n = 6. ns, not significant. **P < 0.01, ****P < 0.0001, #P < 0.0001 compared with 12-month-old APP/PS1 mice. ΔP < 0.0001 compared with 24-month-old WT mice. ▲P < 0.001 compared with 12 m WT mice. P < 0.0001 compared with 12 m APP/PS1 mice.

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