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Table 2 Neuroimaging findings and pathological data

From: Clinical evaluation of neuroinflammation in child-onset focal epilepsy: a translocator protein PET study

Patients

MRI

EEG/MEG

FDG-PETa

[11C]DPA713PET increased uptake

sedation during DPA713PET

TSPO, SNP

Surgeryb

1

Normal

L-F

Normal

No specific uptake

–

HAB

Focal ECoG (I)

2

R-O

R-TO

R-TO

R-O, R > L-T

–

HAB

Focal resection(I)

3

R-T

R-T

R-T

R-T

–

HAB

Focal resection(I)

4

atrophy

Bi-F

R-T

R-cingulate

PTB, LMP

HAB

–

5

R-T

R-T

Bi-T

R-T

–

HAB

Focal resection (I)

6

Multi (L-T)

L-CTO

N.D

L-TPO

THP,MDZ

HAB

P-quadrantectomy (III)

7

Multi

Bi-FTO

N.D

Bi-F

THP,MDZ

HAB

–

8

Normal

R-F, L-F

Normal

No specific uptake

TRF, THP

HAB

Callosotomy (IV)

9

R-FTP

R-FC

R-TP

R-FTP

MDZ,THP,PTZ

HAB

–

10

L-F, R-T

L-F

Bi-F

L-F

THP,PTZ

MAB

Focal resection (II)

11

O (R>L)

L-O

Bi-OPT

Bi-O

–

HAB

Focal resection (I→III)

12

R-F

R-C

R-FT

R-F

–

HAB

–

13

R-F

L-F

R-FT

R-F

–

HAB

–

14

Normal

Bi-F

Normal

L-F

–

HAB

–

15

L-T

Diffuse

L-T

L-T

THP

HAB

Focal resection (II)

16

Normal

L-F, R-FT

Normal

No specific uptake

THP, MDZ

HAB

–

17

MT

R-T

R-F, L-P, T

R-insula, O

DZP

HAB

Focal resection (III)

18

MT

L-T, P, O

N.D

R-F,L-F

THP,MDZ,PTZ

HAB

–

19

Normal

CSWS (R>L)

N.D

Bi-P, R-T

PTB,THP,MDZ,PTZ

HAB

- (corticosteroid effective)

20

Normal

Bi-F

L-FP

R>L insula, cingulate

PTB,THP,MDZ,PTZ

HAB

–

21

MT, SEN

R-F

N.D

R-insula~BG, L-F, P

PTB

HAB

–

22

L-TPO FCD

L-PC

L-TPO

L-TPO

RIS,PTB

HAB

–

23

Normal

L-T/L-P (MEG)

N.D

L-O, L>R hippocampus

–

HAB

EcoG L-O

24

Normal

Bi-F-Diffuse

L-hemisphere

L-FT

DZP

HAB

–

25

MT

L-F, R-F multi

N.D

R-F, L-F, cingulate

PTB

HAB

–

26

L-HME, R-TO FCD

R-TO spike

L-FTP

L-deep WM, R-OT

THP,MDZ

HAB

–

27

Normal

L-insula

Normal

No specific uptake

–

HAB

–

  1. MRI magnetic resonance imaging, EEG electroencephalogram, MEG magnetoencephalography, FDC fludeoxyglucose F18, PET positron emission tomography, TESP translocator protein 18 kDa, R right, SNP single-nucleotide polymorphisms, L left, P posterior, T temporal, O occipital, MT multiple tubers, HME hemimegalencephaly, FCD focal cortical dysplasias, Bi bilateral, BG basal ganglia, WM white matter, CSWS continuous spikes and waves during sleep, PTB Pentobarbital, THP Thiopental, MDZ midazolam, LMP Levomepromazine, RIS Risperidone, TRF Triclofos, PTZ Pentazocine, DZP diazepam, HAB high-affinity binders.