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Table 2 Neuroimaging findings and pathological data

From: Clinical evaluation of neuroinflammation in child-onset focal epilepsy: a translocator protein PET study

Patients MRI EEG/MEG FDG-PETa [11C]DPA713PET increased uptake sedation during DPA713PET TSPO, SNP Surgeryb
1 Normal L-F Normal No specific uptake HAB Focal ECoG (I)
2 R-O R-TO R-TO R-O, R > L-T HAB Focal resection(I)
3 R-T R-T R-T R-T HAB Focal resection(I)
4 atrophy Bi-F R-T R-cingulate PTB, LMP HAB
5 R-T R-T Bi-T R-T HAB Focal resection (I)
6 Multi (L-T) L-CTO N.D L-TPO THP,MDZ HAB P-quadrantectomy (III)
7 Multi Bi-FTO N.D Bi-F THP,MDZ HAB
8 Normal R-F, L-F Normal No specific uptake TRF, THP HAB Callosotomy (IV)
9 R-FTP R-FC R-TP R-FTP MDZ,THP,PTZ HAB
10 L-F, R-T L-F Bi-F L-F THP,PTZ MAB Focal resection (II)
11 O (R>L) L-O Bi-OPT Bi-O HAB Focal resection (I→III)
12 R-F R-C R-FT R-F HAB
13 R-F L-F R-FT R-F HAB
14 Normal Bi-F Normal L-F HAB
15 L-T Diffuse L-T L-T THP HAB Focal resection (II)
16 Normal L-F, R-FT Normal No specific uptake THP, MDZ HAB
17 MT R-T R-F, L-P, T R-insula, O DZP HAB Focal resection (III)
18 MT L-T, P, O N.D R-F,L-F THP,MDZ,PTZ HAB
19 Normal CSWS (R>L) N.D Bi-P, R-T PTB,THP,MDZ,PTZ HAB - (corticosteroid effective)
20 Normal Bi-F L-FP R>L insula, cingulate PTB,THP,MDZ,PTZ HAB
21 MT, SEN R-F N.D R-insula~BG, L-F, P PTB HAB
22 L-TPO FCD L-PC L-TPO L-TPO RIS,PTB HAB
23 Normal L-T/L-P (MEG) N.D L-O, L>R hippocampus HAB EcoG L-O
24 Normal Bi-F-Diffuse L-hemisphere L-FT DZP HAB
25 MT L-F, R-F multi N.D R-F, L-F, cingulate PTB HAB
26 L-HME, R-TO FCD R-TO spike L-FTP L-deep WM, R-OT THP,MDZ HAB
27 Normal L-insula Normal No specific uptake HAB
  1. MRI magnetic resonance imaging, EEG electroencephalogram, MEG magnetoencephalography, FDC fludeoxyglucose F18, PET positron emission tomography, TESP translocator protein 18 kDa, R right, SNP single-nucleotide polymorphisms, L left, P posterior, T temporal, O occipital, MT multiple tubers, HME hemimegalencephaly, FCD focal cortical dysplasias, Bi bilateral, BG basal ganglia, WM white matter, CSWS continuous spikes and waves during sleep, PTB Pentobarbital, THP Thiopental, MDZ midazolam, LMP Levomepromazine, RIS Risperidone, TRF Triclofos, PTZ Pentazocine, DZP diazepam, HAB high-affinity binders.