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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: P2X7R-mediated autophagic impairment contributes to central sensitization in a chronic migraine model with recurrent nitroglycerin stimulation in mice

Fig. 7

Inhibition of P2X7R ameliorated NTG-induced CM associated pain. Chronic treatment with BBG, the specific P2X7R antagonist, significantly relieved NTG-induced basal mechanical hyperalgesia of hind paw (a), and periorbit (c) and alleviated thermal hyperalgesia of hind paw (e). Post-treatment responses were assessed 2 h after NTG administration. BBG prevented NTG-induced acute pain hypersensitivity, including hind paw (b) and periorbital (d) mechanical hyperalgesia and thermal hyperalgesia (f). n = 10 per group; values are expressed as mean ± SEM; two-way ANOVA with a Bonferroni post hoc test were performed; ***p < 0.001 compared with the SHAM group; #p < 0.05, ##p < 0.01, ###p < 0.001 compared with the NTG group

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