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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: P2X7R-mediated autophagic impairment contributes to central sensitization in a chronic migraine model with recurrent nitroglycerin stimulation in mice

Fig. 9

Blocking P2X7R promoted autophagic flux in the TNC after recurrent NTG injection. a–c Representative western blot of autophagy-related proteins after P2X7R inhibition. β-actin was used as the control and band density normalization. The optical density analysis showed that after BBG administration, the ratio of LC3II/LC3I (a) decreased, in combination with reduced expression of p62 (b), without any change in beclin1 (c). n = 6 per group; one-way ANOVA and Tukey’s multiple comparison test; data are presented as mean ± SEM; ***p < 0.001 compared with the SHAM group; ##p < 0.01 compared with the NTG group

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Journal of Neuroinflammation

ISSN: 1742-2094